Table 1. HIV-2 ROD and EHO reference strain aa sequence alteration after H9 cell line passages.
|
HIV-2 ROD (group A)
|
HIV-2 EHO (group B)
|
||||
|---|---|---|---|---|---|
| Env Aa position | Aa in the reference | Aa in the in vitro selected virus | Env Aa position | Aa in the reference | Aa in the in vitro selected virus |
| 727 | R | R/Q | 700 | R | R/Q |
| 728 | G | E | 720 | P | P/L |
| 749 | P | L | 723 | K | K/E |
| 750 | W | STOP | 724 | D | D/E |
| 792 | R | R/K | 725 | R | R/W |
| 793 | D | D/N | 739 | N | N/D |
| 794 | W | W/STOP | 740 | N | N/D |
| 796 | R | R/K | 741 | R | R/G |
| 798 | R | R/K | 747 | P | P/L |
| 800 | A | A/T | 748 | W | STOP |
| 815 | A | T | 756 | P | L |
| 821 | R | R/K | 757 | I | I/F |
| 840 | R | K | 761 | R | R/K |
| 841 | G | G/E | 788 | P | P/L |
| 848 | R | R/K | 793 | P | L |
In the table, we can observe: the Env position of the substitution, the aa substituted and the new aa (X/Y corresponding to a mixture of aa). CT starts at 701st Env position for ROD and 699th for EHO.