Figure 5.

Hyperleukocytosis and stage of differentiation of B-ALL analyzed on the basis of the molecular aberrations. (A) Percentage of cases with hyperleukocytosis (WBC count >50×10⁹/L) in cases with ETV6/RUNX1+ (black bars), E2A/PBX1+ (dark gray bars), MLL1/AF4+ (light gray bars) and BCR/ABL+ (white bars). (B–E) Stage of differentiation within the different molecular aberrations [(B) ETV6/RUNX1; (C) E2A/PBX1+; (D) MLL1/AF4; (E) BCR/ABL+]; the black bars indicate a pro-B ALL, the light gray bars a common ALL and the dark gray bars a pre-B ALL. Detailed P-values are provided in Online Supplementary Tables S2–S9.