Figure 1.

(A) Schematic representation of sugar biosynthetic pathways involving TKDG as an intermediate. Endogenous TDP sugars from E. coli VW187 strain are shown, which are further incorporated as carbohydrate components of the ECA (TDP‐d‐Fuc4NAc) or the O7 polysaccharide (TDP‐l‐rhamnose and TDP‐d‐Qui4NAc). TDP‐l‐mycarose and TDP‐d‐desosamine biosynthetic routes are also described, which are incorporated as sugar components of several polyketides. Genetic organization of the biosynthesis clusters of (B) O7 antigen and (C) ECA. Genes involved in the biosynthetic steps described in this work are highlighted in dark.