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. 2013 Nov 1;8(11):e77899. doi: 10.1371/journal.pone.0077899

Table 2. Liver/body weight ratio and results of biochemical analyses according to the duration of DEN administration in each group.

At 10 weeks of DEN administration
Diet n Body weight (g) Liver weight (g) Liver/body weight (%) ALT (U/L) T.bilirubin (mg/dl) Ammonia (µg/dl)
3% Casein 5 427±31.1 11±1.7 2.6±0.4 59.2±13.48 0.16±0.05 211.8±55.94
3% BCAA 5 420±29.8 9.9±1.2 2.3±0.2 52.6±7.3 0.1±0.00 193.6±23.92
6% BCAA 5 417±20.2 10.3±1.6 2.5±0.3 70±15.59 0.16±0.05 247.25±17.27
At 14 weeks of DEN administration
Diet n Body weight (g) Liver weight (g) Liver/body weight (%) ALT (U/L) T.bilirubin (mg/dl) Ammonia ( µg/dl)
3% Casein 5 463.9±42.3 22.1±5.2 4.8±1.1 126.8±70.46 0.42±0.18 448.4±68.96
3% BCAA 5 464.4±39.6 20.1±4.9 4.3±0.8 105.6±49.45 0.32±0.16 347.2±80.01 *
6% BCAA 5 450±30.2 19.2±3.2 4.3±0.9 109.6±29.67 0.38±0.13 244±45.73 ***
At 16 weeks of DEN administration
Diet n Body weight (g) Liver weight (g) Liver/body weight (%) ALT (U/L) T.bilirubin (mg/dl) Ammonia ( µg/dl)
3% Casein 5 484.7±51.6 27±3.8 5.6±1.0 152.2±61.73 1.45±0.65 415.8±66.27
3% BCAA 5 464.6±36.3 25.6±2.2 5.5±0.8 117±34.63 0.76±0.22 * 361±36.57
6% BCAA 5 457.4±43.7 20.7±3.1 4.5±0.7 * 134.6±23.95 0.6±0.37 * 274.6±32.99 **
At 19 weeks of DEN administration
Diet n Body weight (g) Liver weight (g) Liver/body weight (%) ALT (U/L) T.bilirubin (mg/dl) Ammonia ( µg/dl)
3% Casein 5 494.9±34.1 25.2±3.7 5.1±1.0 122.4±37.75 0.24±0.05 368.6±56.56
3% BCAA 5 515.1±26.2 33.1±7.7 6.5±1.7 170±32.52 0.25±0.06 349.4±28.39
6% BCAA 5 504.4±51.9 31.1±8.7 6.2±1.6 119.2±12.66 0.4±0.16 282.8±30.7 *

Values shown are means ± SD.

*

Significantly different from the 3% casein group at P<0.05.

**

Significantly different from the 3% casein group at P<0.005.

***

Significantly different from the 3% casein group at P<0.0005.