Figure 2. RhoB gene expression and ovary carcinoma differentiation.

RhoB expression levels were analyzed respectively in well-, medium-, and poor-differentiated ovarian cancer using immunohistochemistry staining of individual paraffin sections. RhoB is expressed in the cytoplasm of monolayered ovarian surface epithelial cells for well-differentiated ovary caicinoma (AB); in medium-differentiated tumor, RhoB is expressed in the monolayered and multilayered regions of epithelium tumor (CD); and RhoB is lost in the multilayered region of epithelium for poor-differentiated tumor (EF). (G) It is clear that Poor-differentiated tumors had a significant reduction in the expression of RhoB (80% reduction) than medium differentiated (44% reduction) and well differentiated ovary cancer (28.5% reduction).