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CmeR regulation of gene expression in Campylobacter. In the absence of an inducer, dimeric CmeR binds to target promoters and inhibit the expression of target genes (e.g. cmeABC). In the presence of an inducer (e.g. bile salts), the interaction of an inducer with the C‐terminal ligand‐binding pocket of CmeR triggers a conformational change in the N‐terminal DNA binding domain, preventing the binding of CmeR to target promoters and leading to enhanced expression of target genes.
