Proposed model describing the compartmentalization of the cephalosporin C biosynthetic pathway in A. chrysogenum showing the localization of the CefT and CefM transporters. ACVS, δ‐l‐α‐aminoadipyl‐l‐cysteinyl‐d‐valine synthetase; ACV, l‐δ(α‐aminoadipyl)‐l‐cysteinyl‐d‐valine; IPNS isopenicillin N synthase; IPN, isopenicillin N; IPN‐ACS isopenicillin N‐CoA synthetase; IPN‐ACE; isopenicillin N‐CoA epimerase; PenN, penicillin N; EH, deacetoxycephalosporin synthase (expandase/hydroxylase); DAC, deacetylcephalosporin C; DAC‐AT, deacetylcephalosporin acetyltransferase; CPC, cephalosporin C.