Table 1.
Examples of microbial natural products produced by NRPS/PKS systems.
| Natural product | Microorganism | NRP/PK |
|---|---|---|
| Antibiotics | ||
| Penicillin | Penicillium chrysogenum (fungi) | NRP |
| Bacitracin | Bacillus licheniformis | NRP |
| Tyrocidin | Bacillus brevis | NRP |
| Cephalosporin | Streptomyces clavuligerus | NRP |
| Erythromycin | Saccharopolyspora erythrea | PK |
| Tetracycline | Streptomyces aureofaciens | PK |
| Actinomycin | Streptomyces chrysomallus | NRP |
| Antitumour agents | ||
| Dolastatin 10 | Symploca species (cyanobacteria) | NRP |
| Bleomycin | Streptomyces verticillus | Hybrid NRP/PK |
| Chondramide | Chondromyces crocatus | Hybrid NRP/PK |
| Epothilone | Sorangium cellulosum | Hybrid NRP/PK |
| Immunosuppressants | ||
| Cyclosporin | Tolypocladium inflatum (fungi) | NRP |
| Rapamycin | Streptomyces hygroscopicus | PK |
| FK506 | Streptomyces sp. | PK |
| FK520 | Streptomyces hygroscopicus | PK |
| Protease inhibitors | ||
| Anabaenopeptin | Anabaena flos‐aquae (cyanobacteria) | NRP |
| Oscillamide | Oscillatoria agardhii (cyanobacteria) | NRP |
| Siderophores | ||
| Mycobactin | Mycobacterium tuberculosis | NRP |
| Bacillibactin | Bacillus subtilis | NRP |
| Enterobactin | Escherichia coli | NRP |
| Yersiniabactin | Yersinia pestis | Hybrid NRP/PK |
| Toxins | ||
| Mycolactone | Mycobacterium ulcerans | PK |
| Naphthazarins | Fusarium oxysporum (fungi) | PK |
| HC‐toxin | Cochliobolus carbonum (fungi) | NRP |
Bacteria unless otherwise indicated.