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. 2008 Dec 22;2(1):40–61. doi: 10.1111/j.1751-7915.2008.00063.x

Table 1.

The most frequent amino acid substitutions found in GyrA and ParC of different Enterobacteriaceae.

Microorganism	Amino acid change				MIC (mg l⁻¹) CIP
Microorganism	GyrA		Parc		MIC (mg l⁻¹) CIP
Escherichia coli wt	Ser‐83	Asp‐87	Ser‐80	Glu‐84
	Leu				0.25–4
	Leu		Arg		1–4
	Leu			Lys	4
	Leu	Asn/Tyr			8–128
	Leu	Asn	Arg/Ile		4–128
	Leu	Asn/Tyr	Ile	Val/Lys	64–128
Salmonella spp. wt	Ser‐83	Asp‐87	Ser‐80
	Phe				0.25–2
		Gly/Tyr			0.12–0.5
	Phe		Ile		4

MIC, minimum inhibitory concentration; CIP, ciprofloxacin.