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The most amino acid substitutions found in GyrA and ParC of different microorganisms lacking topoisomerase IV.
| Microorganism | Amino acid change | MIC (mg l−1) | ||
|---|---|---|---|---|
| GyrA | CIP | MOX | ||
| Campylobacter spp. wt | Thr‐86 | Asp‐90 | ||
| Ile | > 32 | 0.38–2 | ||
| Ile | Asn | > 32 | > 32 | |
| Corynebacterium spp. | Ser‐87 | Asp‐91 | ||
| Phe | 1 | 0.19 | ||
| Tyr | 3 | 0.5 | ||
| Phe | Ala | > 32 | 6 | |
CIP, ciprofloxacin; MIC, minimum inhibitory concentration; MOX, moxifloxacin.
