. 2008 Dec 22;2(1):40–61. doi: 10.1111/j.1751-7915.2008.00063.x

Table 4.

Amino acid substitutions found in GyrA and ParC of different Gram‐positive cocci.

Microorganism	Amino acid change				MIC (mg l⁻¹) NOR
Microorganism	GyrA		Parc		MIC (mg l⁻¹) NOR
Staphylococcus aureus wt	Ser‐84	Asp‐88	Ser‐80	Glu‐84 (GrlA)
			Phe		4
	Leu		Phe		16
	Leu		Phe	Lys	128
Streptococcus pneumoniae wt	Ser‐83	Asp‐87	Ser‐79	App‐83
			Tyr/Phe		8
	Tyr		Tyr		64

MIC, minimum inhibitory concentration; NOR, norfloxacin.