Anticoagulant Dosing
Novel oral anticoagulant (DTIs, Factor-Xa inhibitors) dosing guidelines Warfarin initiation dosing guidelines/nomograms Warfarin maintenance dosing guidelines Heparin dosing protocol(s) Intravenous DTI dosing protocols LMWH and fondaparinux dosing guidelines for various indications Use of LMWHs, Factor-Xa inhibitors and DTIs in obesity Use of LMWHs, Factor-Xa inhibitors and DTIs in renal failure and hemodialysis Use of warfarin, UFH, LMWHs, Factor-Xa inhibitors and DTIs in pregnancy Use of warfarin, UFH, LMWHs, Factor-Xa inhibitors and DTIs in pediatric patients Drug interaction recognition and management Use of anticoagulants around neuraxial procedures Thrombolytics dosing and monitoring guidelines Selection and dosing of reversal therapies (Vitamin K, protamine, prothrombin complex concentrate, recombinant Factor VII, etc) Anticoagulant dosing and monitoring in the critically ill patient
Anticoagulant Administration
Infusion pump policies and procedures Acceptable subcutaneous injection sites for anticoagulants Timing of initiation of VTE prophylaxis for surgical and high-risk medical patients Timing of resumption of full-intensity anticoagulation in post-operative patients Time of administration of anticoagulants Accurate patient weight in kilograms
Anticoagulant Monitoring
Target INR, and INR goal range for various indications Frequency of INR monitoring Target aPTT, and aPTT goal range for various indications Frequency of aPTT monitoring Alternative monitoring parameters for special circumstances Required baseline and ongoing laboratory values for various anticoagulants (e.g. CBC with differential, Chem7, ACT, ECT, TT, anti-Factor Xa assay) Patient monitoring for signs and symptoms of bleeding and thrombosis
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