Table 2.
Dysregulated mitochondrial genes in PWS‐IC del mouse muscle and brain tissues (top 10‐fold changes, p < 0.05)
| Up‐regulated genes in PWS‐IC muscle | |||
|---|---|---|---|
| AFFY ID | Gene symbol | Gene description | Fold change |
| 1452771_s_at | FACL3 | Fatty acid coenzyme A ligase, long chain 3 | 1.44 |
| 1418911_s_at | FACL4 | Fatty acid‐coenzyme A ligase, long chain 4 | 1.38 |
| 1417434_at | GPD2 | Glycerol phosphate dehydrogenase 2, mitochondrial | 1.34 |
| 1429533_at | IMMT | Inner membrane protein, mitochondrial | 1.32 |
| 1450612_a_at | PEMT | Phosphatidylethanolamine N‐methyltransferase | 1.31 |
| 1449137_at | PDHA1 | Pyruvate dehydrogenase E1 alpha 1 | 1.268 |
| 1420044_at | NRD1 | Nardilysin, N‐arginine dibasic convertase, NRD convertase 1 | 1.26 |
| 1434996_at | SLC25A16 | Solute carrier family 25 (mitochondrial carrier; Graves disease autoantigen), member 16 | 1.242 |
| 1453886_a_at | SLC25A26 | Solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 26 | 1.24 |
| 1429971_at | TXNRD2 | Thioredoxin reductase 2 | 1.24 |
| Down‐regulated genes in PWS‐IC muscle | |||
| AFFY ID | Gene symbol | Gene description | Fold change |
| 1452257_at | BDH | 3‐Hydroxybutyrate dehydrogenase (heart, mitochondrial) | –2.55 |
| 1422905_s_at | FMO2 | Flavin containing monooxygenase 2 | –2.04 |
| 1422997_s_at | MTE1 | Mitochondrial acyl‐CoA thioesterase 1 | –1.66 |
| 1448988_at | ACADL | Acetyl‐coenzyme A dehydrogenase, long‐chain | –1.56 |
| 1430969_at | MTCH2 | Mitochondrial carrier homolog 2 (C. elegans) | –1.55 |
| 1416203_at | AQP1 | Aquaporin 1 | –1.52 |
| 1450387_s_at | AK4 | Adenylate kinase 4 | –1.49 |
| 1422493_at | CPOX | Coproporphyrinogen oxidase | –1.47 |
| 1444394_at | ACAD9 | Acyl‐Coenzyme A dehydrogenase family, member 9 | –1.42 |
| 1449443_at | DECR1 | 2,4‐Dienoyl CoA reductase 1, mitochondrial | –1.39 |
| 1431148_at | AK3L | Adenylate kinase 3 alpha‐like | –1.34 |
| Up‐regulated genes in PWS‐IC brain | |||
| AFFY ID | Gene symbol | Gene description | Fold change |
| 1451623_at | MRPL15 | Mitochondrial ribosomal protein L15 | 1.98 |
| 1458404_at | NDUFB8 | NADH dehydrogenase (ubiquinone) 1 beta subcomplex 8 | 1.77 |
| 1417823_at | GCAT | Glycine C‐acetyltransferase (2‐amino‐3‐ketobutyrate‐coenzyme A ligase) | 1.55 |
| 1419362_at | MRPL35 | Mitochondrial ribosomal protein L35 | 1.51 |
| 1421829_at | AK4 | Adenylate kinase 4 | 1.46 |
| 1457790_at | ASB3 | Ankyrin repeat and SOCS box‐containing protein 3 | 1.45 |
| 1450948_a_at | MRPL1 | Mitochondrial ribosomal protein L1 | 1.44 |
| 1421874_a_at | MRPS23 | Mitochondrial ribosomal protein S23 | 1.41 |
| 1424164_at | MRPL50 | Mitochondrial ribosomal protein L50 | 1.41 |
| 1422095_a_at | TYKI | Thymidylate kinase family LPS‐inducible member | 1.40 |
| Down‐regulated genes in PWS‐IC brain | |||
| AFFY ID | Gene symbol | Gene description | Fold change |
| 1422008_a_at | AQP3 | Aquaporin 3 | –2100.84 |
| 1417614_at | CKM | Creatine kinase, muscle | –6.85 |
| 1431739_at | MTO1 | Mitochondrial translation optimization 1 homolog (S. cerevisiae) | –1.95 |
| 1442331_at | ALAS1 | Aminolevulinic acid synthase 1 | –1.82 |
| 1430969_at | MTCH2 | Mitochondrial carrier homolog 2 (C. Elegans) | –1.80 |
| 1444489_at | SLC25A12 | Solute carrier family 25 (mitochondrial carrier, Aralar), member 12 | –1.72 |
| 1441030_at | RAI14 | Retinoic acid induced 14 | –1.50 |
| 1453524_at | KIF5B | Kinesin family member 5B | –1.40 |
| 1418987_at | PLA2G2D | Phospholipase A2, group IID | –1.37 |
| 1440579_at | MIB1 | Mindbomb homolog 1 (Drosophila) | –1.31 |