Table 3.
Top 10 list of dysregulated genes in PWS‐IC del mouse muscle and brain tissues (p < 0.05) by Ingenuity
| GENES | Fold change |
|---|---|
| HDC | 7.095 |
| SYNTB1 | 4.346 |
| ONECUT2 | 2.443 |
| EGFL6 | 2.091 |
| ZNF367 | 2.028 |
| ACTC1 | 1.968 |
| IGSF3 | 1.557 |
| CILP | 1.496 |
| CASR | 1.489 |
| NUDT10 | 1.484 |
| Down‐regulated genes (muscle) | |
| GENES | Fold change |
| SNRPN | –537.63 |
| NDN | –14.306 |
| ANXA10 | –13.158 |
| GZMH | –13.021 |
| NEU1 | –2.770 |
| CYFIP2 | –2.732 |
| TBC1D1 | –2.252 |
| DDAH1 | –2.247 |
| Up‐regulated genes (brain) | |
| GENES | Fold change |
| MRPL15 | 1.975 |
| ALOX18 | 1.859 |
| CHRNA5 | 1.781 |
| UBE3A | 1.774 |
| AMN | 1.757 |
| XBP1 | 1.684 |
| DLEU2 | 1.675 |
| CASP1 | 1.622 |
| Down‐regulated genes (brain) | |
| GENES | Fold change |
| SNRPN | –2857.1 |
| NDN | –27.100 |
| ANXA10 | –2.793 |
| SERPINA12 | –2.747 |
| GZMB | –2.740 |
| VAX2 | –2.160 |
| C90RF165 | –2.016 |
| DDXR3Y | –2.008 |