. Author manuscript; available in PMC: 2013 Nov 3.

Published in final edited form as: Kidney Int. 2010 Sep 29;79(1):10.1038/ki.2010.355. doi: 10.1038/ki.2010.355

Table 5.

Stepwise Linear Regression Models using Forward Selection to determine independent effects of Ang-1, Ang-2 and VEGF

Dependent Variable
Independent Variable	Partial R²	Model R²	p-value
Log₁₀ Total Renal Volume
Age	0.2863	0.2863	<.0001
Sex	0.1379	0.4242	0.0006
Log₁₀VEGF	0.0723	0.4965	0.0068
Ang-1	0.0163	0.5128	0.1846
Ang-2	0.0065	0.5193	0.4013
Log₁₀ Total Renal Cyst Volume
Age	0.2722	0.2722	<.0001
Sex (Male)	0.1314	0.4036	0.0010
Log₁₀VEGF	0.0929	0.4966	0.0026
Ang-1	0.0070	0.5036	0.3908
Log₁₀ Total Cyst Number
Sex	0.0941	0.0941	0.0181
Age	0.0698	0.1638	0.0349
Ang-1	0.0490	0.2128	0.0697
Log₁₀VEGF	0.0539	0.2668	0.0513
Ang-2	0.0150	0.2818	0.2973
Log₁₀ LVMI
Log₁₀VEGF	0.3965	0.3965	<.0001
Age	0.1446	0.5412	<.0001
Sex	0.0764	0.6175	0.0009
Log₁₀ Urinary Protein Excretion
Sex	0.1943	0.1943	0.0002
Ang-1	0.0989	0.2932	0.0042
Log₁₀VEGF	0.0143	0.3075	0.2616
ANG2	0.0062	0.3137	0.4607
Log₁₀ Creatinine Clearance
Log₁₀VEGF	0.0801	0.0801	0.0224
Ang-2	0.0308	0.1108	0.1480

Abbreviations: Ang, angiopoietin; VEGF, vascular endothelial cell growth factor.

Note that all models included Log₁₀VEGF, Ang-1, Ang-2 and appropriate covariates. Ratio of Ang-1/Ang-2 was not included owing to significant colinearity with Ang-1 and Ang-2. Entries represent a summary of forward selection with variables that remained in the model and the order of selection. P < 0.15 was required to remain in the model.