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. Author manuscript; available in PMC: 2015 Jan 1.
Published in final edited form as: Biochim Biophys Acta. 2013 Mar 21;1844(1 0 0):10.1016/j.bbapap.2013.03.009. doi: 10.1016/j.bbapap.2013.03.009

Table 1.

Ortholog kinase pairs with conserved enriched function in their substrate set.

Human Kinase Yeast Ortholog Conserved enriched function in substrate set
CDK4 Cdc28 DNA binding; Protein binding
CDK5 Cdc28 Protein binding; DNA metabolism
CDKL5 Ime2 RNA metabolism
CSNK2A2 Cka1 Protein binding
MAPK1 Fus3 DNA metabolism; Chromosome Organization
MAPK1 Kss1 Protein modification; Macromolecule metabolism
MAPK3 Fus3 Macromolecule metabolism
MAPK3 Kss1 Protein modification; Macromolecule metabolism
MAPK7 Fus3 Macromolecule metabolism
MAPK7 Kss1 Protein modification; Macromolecule metabolism
PAK1 Ste20 Regulation of transport
PDPK1 Pkh1 Protein binding
PLK1 YMR001C-A Biological regulation
PRKAA1 Snf1 Development
PRKACA Tpk1 Cell differentiation; Transcriptional regulation
PRKACA Tpk3 Transcriptional regulation; Response to stimulus
PRKY Tpk1 Transcriptional regulation
PRKY Tpk3 Transcriptional regulation; regulation of RNA metabolism
WEE1 Swe1 Transcriptional regulation; Macromolecular metabolism