Figure 4.
Unidirectional and net transepithelial fluxes of oxalate across isolated, short-circuited segments of caecum (n=11 vs 7) and distal colon (n=8 vs 10) of WT mice (not colonized vs mice artificially colonized with HC-1. An asterisk indicates a significant difference between the two groups p ≤ 0.05. Transepithelial conductance (GT) was not significantly affected by colonization in any segment (GT = 19.5 ± 1.7 vs 20.8 ± 1.2 mS/cm2, across caecum, GT = 15.5 ± 2.0 vs 16.5 ± 1.3 mS/cm2 in distal colon of non-colonized mice vs colonized mice, respectively). Isc was not affected by colonization (Isc = 0.5 ± 0.1 vs 0.5 ± 0.1 μEq/cm2 in caecum and Isc = 0.7 ± 0.1 vs 1.3 ±0.1 μEq/cm2 in distal colon of non-colonized mice vs colonized mice, respectively).