Table 1.
Kinetic parameters of M6 metabolism in liver microsomes: Km values are in micromolar values. Vmax values are nanomoles per minute per milligram liver microsomes. The range of substrate concentrations was 7.8 to 2000 µM. Each value is the mean +/− S.D. of three independent experiments.
| Species | Vmax | Km | Vmax/Km |
|---|---|---|---|
| Human | 10.82 +/− 0.47 | 237.2 +/− 32.7 | 45.6 |
| Monkey | 2.99 +/− 0.28 | 424.2 +/− 108.3 | 7.0 |
| Dog | 7.33 +/− 0.43 | 251.1 +/− 42.99 | 29.2 |
| Rat | 8.19 +/− 0.48 | 101.7 +/− 22.62 | 80.5 |
| Mouse | 4.10 +/− 0.19 | 75.7 +/− 12.17 | 54.2 |