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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Mol Nutr Food Res. 2013 Jan 16;57(5):10.1002/mnfr.201200708. doi: 10.1002/mnfr.201200708

Table 1.

Kinetic parameters of M6 metabolism in liver microsomes: Km values are in micromolar values. Vmax values are nanomoles per minute per milligram liver microsomes. The range of substrate concentrations was 7.8 to 2000 µM. Each value is the mean +/− S.D. of three independent experiments.

Species Vmax Km Vmax/Km
Human 10.82 +/− 0.47 237.2 +/− 32.7 45.6
Monkey 2.99 +/− 0.28 424.2 +/− 108.3 7.0
Dog 7.33 +/− 0.43 251.1 +/− 42.99 29.2
Rat 8.19 +/− 0.48 101.7 +/− 22.62 80.5
Mouse 4.10 +/− 0.19 75.7 +/− 12.17 54.2