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. Author manuscript; available in PMC: 2013 Nov 3.
Published in final edited form as: Cell Metab. 2013 Jan 8;17(1):10.1016/j.cmet.2012.12.004. doi: 10.1016/j.cmet.2012.12.004

Figure 1. High and Low Fat Mass Results in Bronchoconstriction.

Figure 1

(A) Diet-induced obese (DIO) WT mice gain significant weight after 12 weeks on a high-fat diet.

(B) Total respiratory resistance (R) and airway resistance (Rn) are increased in DIO-WT mice.

(C) DIO-WT mice have innate airway hyperreactivity (AHR) to methacholine.

(D) Endurance is severely limited in DIO-WT mice when placed on a treadmill.

(E and F) Lypodystrophic, “fat-free,” mice have increased baseline R, Rn, and AHR.

For all panels, n = 10 per group. *p < 0.05, **p < 0.01, and ***p < 0.001. Error bars represent SEM. See also Figure S1.