(A) Diet-induced obese (DIO) WT mice gain significant weight after 12 weeks on a high-fat diet.
(B) Total respiratory resistance (R) and airway resistance (Rn) are increased in DIO-WT mice.
(C) DIO-WT mice have innate airway hyperreactivity (AHR) to methacholine.
(D) Endurance is severely limited in DIO-WT mice when placed on a treadmill.
(E and F) Lypodystrophic, “fat-free,” mice have increased baseline R, Rn, and AHR.
For all panels, n = 10 per group. *p < 0.05, **p < 0.01, and ***p < 0.001. Error bars represent SEM. See also Figure S1.