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. Author manuscript; available in PMC: 2013 Nov 3.
Published in final edited form as: Curr Opin Immunol. 2013 Feb 14;25(2):10.1016/j.coi.2013.01.004. doi: 10.1016/j.coi.2013.01.004

Figure 1.

Figure 1

TNFR family members OX40, 4-1BB, and CD40 have unique roles in regulating anti-tumor T cell responses. OX40 is expressed at much higher levels on activated CD4 T cells than CD8 T cells whereas 4-1BB is more highly expressed on CD8 T cells than CD4s. APCs in the tumor microenvironment express low levels of CD40 and activated T cells express both pre-formed CD40L and rapidly increase CD40L on the cell surface after antigen encounter. Tumor cells themselves are also targeted by agonist antibodies via ADCC. Therefore, targeting these TNFR family members with agonist antibodies promotes intra-tumor effector T cell responses and tumor regression.