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. Author manuscript; available in PMC: 2013 Nov 3.
Published in final edited form as: Basic Clin Pharmacol Toxicol. 2013 May 20;113(2):92–102. doi: 10.1111/bcpt.12071

Figure 1. Chemical structure and representative chromatograms of (R) and (S) bicalutamide-glucuronide.

Figure 1

(A and B) Bicalutamide (A) is a pure non-steroidal anti-androgen used in clinic as a racemate of R and S enantiomers. Both enantiomers can be glucuronidated (B).

(C and D) Representative chromatograms of (R)bicalutamide-glucuronide (C) and (S)-glucuronide (D) as obtained from incubated samples. Retention times were 3.1 minutes (min) for (R)bicalutamide-glucuronide and 3.9 minutes for (S)bicalutamide-glucuronide and deuterated internal standard (S)bicalutamide-G, d4.

G: glucuronide; min: minute; cps: count per second