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. Author manuscript; available in PMC: 2014 Oct 1.
Published in final edited form as: Cancer Res. 2013 Aug 21;73(19):10.1158/0008-5472.CAN-13-0453. doi: 10.1158/0008-5472.CAN-13-0453

Figure 5. Inactivation of E2F1/FOXO transcriptional associates with poor prognosis in breast and lung cancer.

Figure 5

A. Expression data for the E2F1/FOXO signature described above (Table S3) was extracted from the previously compiled combined BC1143 breast cancer dataset of 1143 tumors (36). This dataset consists of ten independent publicly available datasets representing various subtypes and stages of breast cancer. Genes and samples were clustered using unsupervised hierarchical clustering as described in Methods. Red color indicates high expression and green color indicates low expression.

B. 574 patients from the BC1143 dataset, for which survival data was available, were stratified into two groups according to the clustering results in (A) and survival curves were constructed for each group.

C, D Five year survival analysis of 275 lung cancer patients was performed as in A, B using a publicly available dataset (37).