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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Kidney Int. 2013 May 15;84(5):920–930. doi: 10.1038/ki.2013.175

Figure 2.

Figure 2

Progressive glomerulosclerosis in podoCdc42−/− but not podoRac1−/− mice by light microscopy (PAS staining at 20× and 40× magnification). (A, B) Floxed control mice demonstrate normal tubulointerstitial and glomerular morphology at 3-4 weeks of age. (C, D) podoRac1−/− tubulointerstitial and glomerular morphology at 12 months of age is indistinguishable from control. Podocyte-specific loss of Cdc42 results in tubular protein casts and injury (E) as well as focal segmental glomerulosclerosis in a minority of glomeruli (F) at 3-4 weeks of age.