Table 1.

Post-translational modifications of Hsp90. p300, histone acetyl transferase; CK2, casein kinase II; PKA, protein kinase A; DNA-PK, DNA-dependent protein kinase; eNOS, endothelial nitric oxide synthase.

Modification	Hsp90 residue (α)	Enzyme	Result	Reference
4-HNE, 4-ONE	C572		Decreased client association	99
Acetylation	K294	HDAC6	Decreased client association	100
Acetylation	K69, K100, K292, K327, K546, K558	p300, HDAC6	Increased inhibitor binding, increased extracellular expression	74,101–104
Dephosphorylation		Ppt1/PP5	Decreased chaperone function	105
Phosphorylation	Y309	SRC	VEGFR2-induced angiogenesis	106
Phosphorylation	S231, S263	CK2	Increased apoptosome formation, decreased client association	107,108
Phosphorylation	Y38	Swe1/Wee1	Increased client association, decreased inhibitor binding	109,110
Phosphorylation	T36	CK2	Decreased ATPase activity, increased inhibitor binding	111,112
Phosphorylation	Y197	Yes	Decreased co-chaperone association	113
Phosphorylation	Y309	Yes	Increased co-chaperone association	113
Phosphorylation	T5, T7	DNA-PK	Increased extracellular expression	75,114
Phosphorylation	T		P2X7 receptor repressor	115
Phosphorylation	S263	B-Raf	Unknown	116
Phosphorylation	S460	PKA	Unknown	117
Phosphorylation	T90	PKA	Increased extracellular expression, decreased client association	84,118
S-nitrosylation	C597	eNOS	Decreased chaperone function, decreased ATPase activity	119,120
Ubiquitination			Decreased client association	121