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. Author manuscript; available in PMC: 2014 Sep 19.
Published in final edited form as: Chem Biol. 2013 Sep 12;20(9):10.1016/j.chembiol.2013.08.004. doi: 10.1016/j.chembiol.2013.08.004

Figure 5. Tumor detection limits and specificity using optical or radioiodinated tethered Hsp90 inhibitors.

Figure 5

(A) One hour post injection IVIS kinetic images of mice bearing MDA-MB-468 tumors and injected with HS-27, HS-105 or control. (B) 24 hours post injection IVIS Kinetic images of excised tissues from SCID mice bearing MDA-MB-468 tumors and injected with HS-27, HS-105 or control. Liver (L) and lung (R) are in the top rows and the tumors are in the bottom row. (C) The IVIS average radiant efficiency plotted against the concentration of HS-27, mean ± SEM. (D,E) The IVIS average radiant efficiency of live mice injected with MDA-MB-468 cells treated ex vivo with HS-70 or control, mean ± SDM. (F-I) MCF7 and Huh7 cells treated with [125I]HS-111 and cell lysates fractioned on a mono Q anion exchange column. (F) MCF7 and Huh7 cells under normal conditions, (G) MCF7 cells treated with and without HS-10 (H) MCF7 and Huh7 cells with β-escin, (I) MCF7 and Huh7 cells with β-escin and HS-10. *P value = 0.0424. See also Figure S6.