Table 1.
Clinical Characteristics and Hemodynamics
| Cohort | IPAH (n=67) |
SScPAH (n=166) |
P-value (IPAH vs. SScPAH) |
SSc-ILD-PH (n=49) |
P-value (SScPAH vs. SSc- ILD-PH) |
|---|---|---|---|---|---|
| Gender | |||||
| Female (%) | 53 (79) | 145(87) | 0.16† | 33(67) | 0.002† |
| Race | |||||
| Caucasian (%) | 50 (75) | 133(80) | 0.07‡ | 17(35) | <0.001‡ |
| African American (%) | 12 (18) | 19(11) | - | 7(14) | - |
| Asian/Pacific Islander (%) | 1 (1) | 1 (1) | - | 8(16) | - |
| Hispanic/Latino (%) | 3 (4) | 10(6) | - | 15(31) | - |
| Other/Unknown (%) | 1 (1) | 3(2) | - | 2(4) | - |
| Age at catheterization (in years) | 48 ± 14 | 60 ± 11 | <0.001 | 54 ± 11 | 0.002 |
| Body Surface Area (m2) | 1.81 ± 0.35 | 1.75 ± 0.21 | 0.028 | 1.70 ± 0.22 | 0.26 |
| Body Mass Index (kg/m2) | 31.3 ± 10.4 | 27.8 ± 6.7 | 0.002 | 24.4 ± 5.6 | 0.001 |
| Serum Creatinine (mg/dL) | 0.89 ± 0.25 (n=60) |
1.11 ± 0.56 (n=148) |
0.001 | 0.96 ± 0.54 (n=46) |
0.004 |
| Mean PAP (mmHg) | 51 ± 14 | 41 ± 13 | <0.001 | 40 ± 11 | 0.70 |
| Systolic PAP (mmHg) | 83 ± 23 | 67 ± 22 | <0.001 | 63 ± 17 | 0.32 |
| Diastolic PAP (mmHg) | 32 ± 11 | 25 ± 10 | <0.001 | 26 ± 8 | 0.40 |
|
Pulmonary Pulse Pressure (mmHg) |
51 ± 16 | 42 ± 15 | <0.001 | 38 ± 12 | 0.07 |
| Cardiac Output (L/min) | 4.4 ± 1.5 | 4.5 ± 1.5 | 0.76 | 4.7 ± 1.5 | 0.37 |
| Cardiac Index (L/min/m2) | 2.4 ±0.8(n=61) | 2.6±0.8(n=162) | 0.16 | 2.8 ± 0.9 | 0.06 |
|
Pulmonary Artery O2 Saturation(%) |
65 ± 8(n=66) | 65 ± 9(n=125) | 0.76 | - | - |
| Stroke Volume (mL) | 56 ± 21 | 56 ± 20 | 0.88 | 54 ± 17 | 0.63 |
| Heart Rate (beats per min) | 82 ± 13 | 82 ± 13 | 0.61 | 88 ± 13 | 0.01 |
| Right Atrial Pressure (mmHg) | 9 ± 5 (n=66) | 8 ± 5 | 0.71 | 7 ± 4 | 0.07 |
| PCWP (mmHg) | 10 ± 3 | 10 ± 3 | 0.76 | 10 ± 3 | 0.95 |
| RPA (mmHg*S*mL−1) | 0.63 ± 0.33 | 0.50 ± 0.36 | 0.001 | 0.45 ± 0.26 | 0.64 |
| RPA (Wood units) | 10.4 ± 5.5 | 8.4 ± 5.9 | 0.001 | 7.4 ± 4.3 | 0.64 |
| CPA (mL mmHg−1) | 1.3 ± 0.8 | 1.6. ±1.1 | 0.028 | 1.7 ± 1.0 | 0.41 |
| Pulmonary RC time (seconds) | 0.59 ± 0.14 | 0.54 ± 0.13 | 0.009; 0.81¥ |
0.56 ± 0.18 | 0.93; 0.31¥ |
| Systemic MAP (mmHg) | 89 ± 11(n=65) | 89 ± 15 | 0.46 | 87 ± 4(n=45) | 0.52 |
| Systemic RC time (seconds) | 1.30 ± 0.41 | 1.18 ± 0.44 | 0.01; 0.76¥ |
1.14 ± 0.34 | 0.97; 0.13¥ |
*
Continuous variables shown as mean ± SD
Student t-test or Mann-Whitney Rank Sum Test as appropriate unless otherwise indicated
†
Chi-Square Test
‡
Fisher Exact Test
¥
Multiple Linear Regression Model (adjusted for age and mean pressure)
PAP = Pulmonary Artery Pressure, 02 = Oxygen; PCWP = Pulmonary capillary wedge pressure; MAP = Mean Arterial Pressure; RPA = Pulmonary Vascular Resistance; CPA = Pulmonary Arterial Compliance
Creatinine data within 60 days of right heart catheterization