Table 2.
Pressure-Volume Loop Data and Hemodynamics
| Cohort | IPAH (n=5) |
SScPAH (n=7) |
P -Value (IPAH vs. SScPAH ) |
SSc-no- PAH (n=7) |
P-Value (SScPA H vs. SSc-no- PAH) |
|---|---|---|---|---|---|
| WHO Functional Class | 2.0 ± 0.7 | 2.6 ± 0.5 | 0.14 | n/a | n/a |
| Age at catheterization (years) | 48 ± 13 | 56 ± 11 | 0.26 | 57 ± 13 | 0.89 |
| Body Surface Area (m2) | 1.90 ± 0.30 | 1.82 ± 0.24 | 0.62 | 1.85 ± 0.25 | 0.83 |
| Hemodynamics and Volumes | |||||
| Mean Pulmonary Artery Pressure (mmHg) | 49 ± 21 | 37 ± 12 | 0.23 | 18 ± 3 | 0.002 |
| Cardiac Index (L/min/m2) | 2.4 ± 0.6 | 2.4 ± 0.8 | 0.88 | 2.9 ± 0.3 | 0.46 |
| Pulmonary Artery Oxygen Saturation (%) | 67 ± 7 | 62 ± 3 | 0.12 | 72 ± 3 | <0.001 |
| Right Atrial Pressure (mmHg) | 7 ± 3 | 8 ± 4 | 0.58 | 6 ± 2 | 0.17 |
| Pulmonary Capillary Wedge Pressure (mmHg) |
11 ± 3 | 10 ± 4 | 1.0 | 8 ± 3 | 0.33 |
| Mean Systemic Artery Pressure (mmHg) | 86 ± 15 | 86 ± 8 | 0.76 | 94 ± 9 | 0.13 |
| Right Ventricular End Diastolic Volume (mL) |
161 ± 47 | 130 ± 45 | 0.28 | 128 ± 32 | 0.94 |
| RV afterload | |||||
| Pulmonary Arterial Compliance (mL mmHg−1) | 1.7 ± 1.1 | 2.4 ± 1.5 | 0.42 | 4.0 ± 1.6 | 0.053 |
| Pulmonary Vascular Resistance (Wood units) | 7.9 ± 4.3 | 7.0 ± 4.5 | 0.74 | 1.8 ± 0.8 | 0.011 |
| Pulmonary Vascular Resistance (mmHg*S*ml−1) |
0.47 ± 0.26 | 0.42 ± 0.27 | 0.74 | 0.11 ± 0.05 | 0.011 |
| Effective Arterial Elastance | 1.2 ± 0.5 | 0.9 ± 0.4 | 0.30 | 0.4 ± 0.1 | 0.001 |
| RV Systolic Function (Contractility) | |||||
| RV Ejection Fraction (%) | 43 ± 13 | 47 ± 12 | 0.43 | 57 ± 1 | 0.09 |
| RVSWI (mmHg*m−2*L−1) | 18.8 ± 9.7 | 12.5 ± 5.9 | 0.19 | 5.5 ± 1.9 | 0.011 |
| End Systolic Elastance (Ees) | 2.3 ± 1.1 | 0.8 ± 0.3 | 0.007 | 0.9 ± 0.6 | 0.73 |
| V0 (x-intercept of end systolic elastance) | 46 ± 37 | −31 ± 49 | 0.016 | 21 ± 28 | 0.033 |
| End Systolic Elastance (normalized) (Eesnorm) |
3.1 ± 1.4 | 0.9 ± 0.3 | 0.002 | 1.1 ± 0.7 | 0.43 |
| Preload Recruitable Stroke Work (Mw) | 45 ± 16 | 21 ± 11 | 0.011 | 20 ± 12 | 0.83 |
| RV Diastolic Function | |||||
| Peak Fill Rate/End Diastolic Volume (ms/mL) |
2.7 ± 0.9 | 2.9 ± 0.9 | 0.79 | 3.4 ± 1.1 | 0.33 |
| Tau (Glantz) (ms) | 105 ± 47 | 106 ± 18 | 0.94 | 131 ± 86 | 1.0 |
| Tau (Suga) (ms) | 36 ± 9 | 39 ± 6 | 0.50 | 39 ± 12 | 0.94 |
| dp/dt/Min (mmHg/ms) | −687 ± 274 | −420 ± 120 | 0.07 | −262 ± 63 | 0.009 |
| RV-Pulmonary Artery Coupling | |||||
| Ees/Ea | 2.1 ± 1.0 | 1.0 ± 0.5 | 0.03 | 2.3 ± 1.2 | 0.016 |
*
Continuous variables shown as mean ± SD
Student t-test or Mann-Whitney Rank Sum Test as appropriate
RVSWI = Right Ventricular Stroke Work Index