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. Author manuscript; available in PMC: 2014 May 1.
Published in final edited form as: Nat Neurosci. 2013 Sep 29;16(11):1644–1651. doi: 10.1038/nn.3533

Figure 7. Reversing the maturation of silent synapses in the BLA-to-NAc projection reverses incubation of cocaine craving.

Figure 7

(A) Diagrams showing the timeline of behavioral experiments and the LTD induction protocol in BLA-to-NAc synapses before the test for cue-induced cocaine seeking on withdrawal day 45. (B) Summary showing that after 45 days of withdrawal from cocaine, EPSCs at BLA-to-NAc synapses were significantly inhibited by perfusion of Naspm. After in vivo LTD induction, EPSCs from these synapses became resistant to Naspm. EPSCs were insensitive to Naspm before or after in vivo LTD in saline-experienced rats. (C) In vivo LTD induction prevented incubated cue-induced cocaine seeking in the extinction test. Error bar, s.e.m. ** p<0.01.