Table 2. Incidence, stratified by NLST Inclusion, all datasets pooled.

Dataset	Cut-offs	Two-stratum				Four-stratum
		Positivity (C/N) (PPV, 1/PPV)		Negativity (C/N) [NPV, 1/(1-NPV)]		Positivity (C/N) (PPV, 1/PPV)			Negativity (C/N) [NPV, 1/(1-NPV)]
		Current positive		Current negative		High positive	Positive		Negative	Low negative
NLSTa (116C/415N)	Incidence Unadjusted 2.7%	43/36 37%/9% (0.106, 1 in 9)		73/379 63%/91% (0.981, 1 in 53)		31/9 27%/2% (0.255, 1 in 4)	12/27 10%/7% (0.042, 1 in 24)		56/270 48%/65% (0.980, 1 in 50)	17/109 15%/26% (0.985, 1 in 66)
Non-NLSTb (328C/943N)	Incidence Unadjusted 2.7%	103/89 31%/9% (0.085, 1 in 12)		225/854 69%/91% (0.979, 1 in 49)		61/23 19%/2% (0.175, 1 in 6)	42/66 13%/7% (0.048, 1 in 21)		198/595 60%/63% (0.974, 1 in 39)	27/259 8%/28% (0.992, 1 in 121)
cP-value		0.91		0.03		0.56	0.37		0.005	0.22
dP-value		C 0.26/N 0.65				C 0.03/N 0.91

^aIndividuals who met the NLST criteria for lung cancer screening; ^bIndividuals who did not meet the NLST criteria for lung cancer screening; ^cAssociation of Cancer status and NLST eligibility using χ² test; ^dAssociation of EarlyCDT-Lung positivity and NLST eligibility using χ² test. C, cancers; N, normals (cancer-free controls).