Table 3. Incidence, stratified by NLST Inclusion: case-control and population set separate.

Dataset	Dataset	Cut-offs	Two-stratum				Four-stratum
			Positivity (C/N) (PPV, 1/PPV)		Negativity (C/N) [NPV, 1/(1-NPV)]		Positivity (C/N) (PPV, 1/PPV)			Negativity (C/N) [NPV, 1/(1-NPV)]
			Current positive		Current negative		High positive	Positive		Negative	Low negative
Case-control (409C/617N)	NLSTa (98C/167N)	Incidence Unadjusted 2.7%	38/17 39%/10% (0.096, 1 in 10)		60/15 61%/90% (0.981, 1 in 54)		29/5 30%/3% (0.215, 1 in 5)	9/12 9%/7% (0.034, 1 in 29)		47/117 48%/70% (0.981, 1 in 54)	13/33 13%/20% (0.982, 1 in 55)
	Non-NLSTb (311C/450N)	Incidence Unadjusted 2.7%	95/41 31%/9% (0.085, 1 in 12)		216/409 69%/91% (0.979, 1 in 48)		56/14 18%/3% (0.138, 1 in 7)	39/27 13%/6% (0.055, 1 in 18)		191/304 61%/68% (0.975, 1 in 41)	25/105 8%/23% (0.991, 1 in 106)
aP-value			0.92		0.11		0.51	0.19		0.02	0.20
bP-value			C 0.13/N 0.69				C 0.02/N 0.78
Population (35C/741N)	NLSTa (18C/248N)	Incidence Unadjusted 2.7%	5/19 28%/8% (0.091, 1 in 11)		13/229 72%/92% (0.979, 1 in 47)		2/4 11%/2% (0.160, 1 in 6)	3/15 17%/6% (0.071, 1 in 14)		9/153 50%/62% (0.978, 1 in 45)	4/76 22%/31% (0.980, 1 in 51)
	Non-NLSTb (17C/493N)	Incidence Unadjusted 2.7%	8/48 47%/10% (0.118, 1 in 8)		9/445 53%/90% (0.984, 1 in 62)		5/9 29%/2% (0.309, 1 in 3)	3/39 18%/8% (0.058, 1 in 17)		7/291 41%/59% (0.981, 1 in 53)	2/154 12%/31% (0.990, 1 in 97)
cP-value			0.47		0.01		0.92	0.26		0.07	0.09
dP-value			C 0.24/N 0.35				C 0.54/N 0.79

^aIndividuals who met the NLST criteria for lung cancer screening; ^bIndividuals who did not meet the NLST criteria for lung cancer screening; ^cAssociation of Cancer status and NLST eligibility using χ² test; ^dAssociation of EarlyCDT-Lung positivity and NLST eligibility using χ² test. C, cancers; N, normals (cancer-free controls).