Figure 4.

Surface representation of the substrate access pathways in the 3A6 protein. The upper panel (A, C, E, G) corresponds to the wild‐type protein whereas the bottom panel (B, D, F, H) correspond to the model containing the corresponding mutation. Panels G and H represent the wild‐type protein oriented with a difference of 90°C (in red is shown the C‐terminal part which is removed after N³¹⁶STOP mutation). In all cases, the catalytic core is shown in green colour, where as the original or new introduced mutation are shown in pink or red colour. Panel I illustrates the view of the Gly¹⁷⁸‐Gly²¹¹ insertion related to the catalytic core (green).