A, B. Brain volume and isocortical volume in the rat (n = 3 – 4/age/group) increased significantly with age in both groups, and were both significantly lower in the EtOH than in the M/D group at all three ages [postnatal day (P)0, P3, P6]. C. Isocortical FA in both treatment groups decreased significantly with age. Additionally, across age groups, the maltose/dextrin (M/D) had the lowest mean isocortical FA, while the ethanol (EtOH) group had the highest FA. D. The anisotropy index (AI) for a subset of subjects (1–3/age/group), in both treatment groups decreased significantly with age. Additionally, across age groups, the maltose/dextrin (M/D) group had the lowest mean isocortical AI, while the ethanol (EtOH) group had the highest AI. Numbers of subjects in each group at each age are represented on the x-axes above the age group labels. Please note that for the brain volume, isocortical volume and FA analyses, numbers represent numbers of subjects. For the AI analysis numbers represent the numbers of histological slices included in the analysis. Statistical results for effects of age and group on each dependent variable are represented in each graph in the form of p-values.