Table 1.
Most important identified targets of the miR-29 family, regulating fibrosis and extracellular matrix remodeling in different organs and tissues.
| Validated targets of miR-29 | Species | Organ; tissue | Reference |
|---|---|---|---|
| ADAM12 | Human | Lung | Cushing, L. 2010 |
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| ADAMTS9 | Human | Lung | Cushing, L. 2010 |
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| COL1A1 | Human/mouse | Aorta, heart, kidney, liver, lung, skin | Boon, R. 2011, Kwiecinski, M. 2011, Maegdefessel, L. 2012, Maurer, B. 2010, Qin, W. 2011, Van Rooij, E. 2008 |
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| COL1A2 | Human/mouse | Lung, liver | Cushing, L. 2010, Sekiya, Y. 2011 |
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| COL2A1 | Human/mouse | Aorta, heart, kidney, liver, lung | Boon, R 2011, Kwiecinski, M. 2011, Maegdefessel, L. 2012, Maurer, B. 2010, Qin, W. 2011, Van Rooij, E. 2008 |
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| COL3A1 | Human/mouse | Aorta, heart, kidney, liver, lung, skin | Boon, R. 2011, Kwiecinski, M. 2011, Maegdefessel, L. 2012, Qin, W. 2011, Van Rooij, E. 2008 |
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| COL4A1 | Human | Kidney | Wang, B. 2012 |
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| COL4A2 | Human/mouse | Bone (osteoblasts), Lung | Cushing, L. 2010, Li, Z. 2009 |
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| Col5a1 | Mouse | Aorta | Maegdefessel, L. 2012 |
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| Col5a3 | Mouse | Bone (osteoblasts) | Li, Z. 2009 |
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| COL6A2 | Human/mouse | Lung | Garbacki, N. 2011 |
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| COL7A1 | Human | Uterus (endometrium) | Hawkins, S.M. 2011 |
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| COL15A1 | Human | Lung | Cushing, L. 2010 |
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| COL21A1 | Human | Uterus (endometrium) | Hawkins, S.M. 2011 |
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| ELN | Human/mouse | Aorta, heart | Boon, R 2011, Maegdefessel, L. 2012, Van Rooij, E. 2008, Zhang, P. 2011 |
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| FBN1 | Human/mouse | Aorta, heart | Maegdefessel, L. 2012, Van Rooij, E. 2008 |
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| FN1 | Human | Liver | Sekiya, Y. 2011 |
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| MCL1 | Human/mouse | Aorta | Merk, D. 2011 |
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| MMP2 | Human/mouse | Aorta, prostate | Chen, K.C. 2011, Maegdefessel, L 2012, Steele, R 2010 |
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| MMP9 | Human/mouse | Aorta | Chen, K.C. 2011, Maegdefessel, L 2012 |
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| MMP15 | Human/mouse | Lung | Garbacki, N. 2011 |
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| MMP24 | Human/mouse | Lung | Garbacki, N. 2011 |
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| TGFB1 | Human | Eye (trabecular meshwork) | Luna, C. 2011 |
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| TGFB2 | Human | Eye (trabecular meshwork) | Luna, C. 2011 |
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| Tgfb3 | Mouse | Bone (osteoblasts) | Li, Z. 2009 |
ADAM metallopeptidase domain 12 = ADAM12, ADAM metallopeptidase with thrombospondin type 1 motif, 19 = ADAMTS9, collagen = COL, elastin = ELN, fibrillin 1= FBN1, fibronectin 1 = FN1, myeloid cell leukemia sequence 1 = MCL1, matrix metallopeptidase isoforms = MMP, transforming growth factor beta = TGFB