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Transcriptional regulation of K15 keratin gene expression by the AP-1 and NF-κB transcription factors. Construct containing the K15 promoter was cotransfected into HeLa cells with constructs expressing AP-1 proteins c-Fos, c-Jun, and Fra-1, individually or in combination (A), or NF-κB proteins p50, p65, and c/Rel, individually or in combination (B). The basal activity of the K15 wt-CAT construct was considered to be 1.
