Table 2.

Pharmacokinetic parameters of tanshinons in 12 healthy volunteers after single- and multiple-dose administration of the ethanol extract of danshen.

PK parameter	Tanshinone I	Cryptotanshinone	Tanshinone IIA	Dihydrotanshinone I
C max⁡ (ng/mL)	11.52 ± 9.90	3.44 ± 1.32	4.00 ± 2.79	0.85 ± 0.59
C trough (ng/mL)	3.09 ± 1.09	0.76 ± 0.23	1.36 ± 0.52	0.20 ± 0.15
C ssmax (ng/mL)	18.10 ± 16.44	3.33 ± 1.85	3.98 ± 1.97	1.00 ± 0.56

Data are mean value ± SD.

C _max⁡: peak plasma concentration after single-dose administration of the danshen extract; C _trough: plasma trough concentration at the end of a dosing interval after multiple-dose administration of the danshen extract; C _ssmax: peak plasma concentration at the end of a dosing interval after multiple-dose administration of the danshen extract.