Fig. 2.

Ntf4^−/− mice lose geniculate ganglion neurons between E10.5 and E11.5, and these losses continue to increase until E18.5 of development. Total neuron numbers were plotted at E11.5, E12.5, E14.5, E16.5 and E18.5 in Ntf4^−/− and wild type mice (A). The first significant loss in neuron number in Ntf4^−/− mice occurred at E11.5, and losses continued until E16.5 of development. The reduction in geniculate ganglion volume in Ntf4^−/− compared with wild type mice did not occur until E12.5; however, following this age, reductions in geniculate volume reflected the losses in neuron number (B) versus wild type. *p≤0.05, **p≤0.01 and ***p≤0.001.