Figure 2. Figure illustrating some of the major roles of developmental regulators including ontogenetic transcriptional regulators, cytokine receptors, and other factors in various stages of development of cortical PV, SST, and calretinin neurons.

This figure is based on published reports that largely utilized single, complete loss of gene function murine models. This list of factors is not exhaustive, and many of the factors may play additional roles beyond those listed here. Since many gene mutations are lethal postnatally, knowledge of the potential role of many factors in postnatal maturation and survival is not known. Full gene name and associated references: Arx: aristaless related homeobox (Colombo et al., 2007); COUP-TFII: chicken ovalbumin upstream promoter-transcription factor II (Kanatani et al., 2008; Reinchisi et al., 2012); CXCR4 and CXCR7: chemokine (C-X-C motif) receptors 4 and 7 (Wang et al., 2011; Sanchez-Alcaniz et al., 2011; Meechan et al., 2012); Dlx1: Distal-less homeobox 1 (Cobos et al., 2005); Dlx5/6: Distal-less homeobox 5/6 (Wang et al., 2010); ErbB4: receptor tyrosine-protein kinase erbB-4 (Flames et al., 2004; Fazzari et al., 2010; Ting et al., 2011); Gsx2: genomic screened homeobox 2 (Fogarty et al., 2007); Lhx6: LIM homeodomain factor 6 (Liodis et al., 2007; Zhao et al., 2008; Neves et al., 2012); Nkx2.1: NK2 homebox 1 (Sussel et al., 1999; Xu et al., 2004; Butt et al., 2008; Nobrega-Pereira et al., 2008); Nkx6.2: NK6 homeobox 2 (Fogarty et al., 2007); SATB1: Special AT-rich DNA Binding Protein 1 (Denaxa et al., 2012); Sox6: SRY (sex determining region Y)-box 6 (Azim et al., 2009; Batista-Brito et al., 2009); Zeb2/Sip1/Zfhx1b: zinc finger E-box binding homeobox 2 (van, V et al., 2013; McKinsey et al., 2013).