Figure 1.

Outcome definitions: We studied probability of prednisone and calcineurin-inhibitor-free remission (top) for at least 6 and 12 months (primary outcomes; no children were excluded from these analyses). Remission (absence of proteinuria) could be attained with complete withdrawal of both prednisone (P) and calcineurin-inhibitors (C) or either of them. We studied also time to relapse (proteinuria or need to reintroduce prednisone or calcineurin-inhibitors) after successful tapering (bottom). This analysis included only children who completed drug withdrawal, as children who failed to complete drug withdrawal could not be considered at risk for relapse (secondary outcome).