Table 1.
Baseline Characteristics by age above and below the sample median (9.4 years). Most data are given as mean±SD.
| All | Age≤9.4 | Age>9.4 | P | |
|---|---|---|---|---|
| N=46 | N=23 | N=23 | ||
| Ages (yr) | 9.9±4.3 | 6.5±2.0 | 13.4±3.1 | <0.01 |
| Creatinine clearance ml/min | 98±13 | 96±10 | 100±15 | 0.29 |
| Total cholesterol mg/dL | 181±15 | 182±16 | 180±15 | 0.66 |
| Serum albumin gr/dL | 3.6± | 3.5±0.4 | 3.6±0.4 | 0.40 |
| Duration years mean±SD | 6.3±4.1 | 3.4±2.0 | 9.2±3.5 | <0.01 |
| 1 – 3 years (%) | 11 (24) | 11 (48) | 0 (0) | |
| 3 – 6 years (%) | 17 (37) | 12 (52) | 5 (22) | <0.01 |
| > 6 years (%) | 18 (39) | 0 (0) | 18 (78) | |
| Body Weight | 37.1±15.6 | 25.7±9.3 | 48.4±11.9 | <0.01 |
| Renal Histology n° | 16 | 5 | 11 | |
| Not performed | 30 | 18 | 12 | |
| FSGS | 2 | 0 | 2 | 0.999 |
| MCN | 10 | 4 | 6 | |
| IgM | 4 | 1 | 3 | |
| Prednisone (mg/kg/d) | 0.4±0.3 | 0.5±0.3 | 0.3±0.2 | 0.04 |
| CyA mg/Kg/d (n) | 2.5±1.2 (17) | 2.9±1.2 | 2.3±1.2 | 0.277 |
| FK mg/Kg/d (n) | 0.12±0.02 (19) | 0.11±0.005 | 0.12±0.01 | |
| Male | 29 (63%) | 16 (69%) | 13 (56%) | 0.359 |
| Toxicity | 17 (37%) | 4 (17%) | 13 (56%) | <0.01 |
| ACEI/ARB | 31 (67%) | 17 (74%) | 14 (61%) | 0.345 |
(*)
Doses of Tacrolimus (FK) are expressed in Cyclosporine A (CyA) equivalent doses; ACEI/ARB indicates ACE-inhibitors or angiotensin receptor blockers