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. 2013 Oct 7;2(10):e76. doi: 10.1038/oncsis.2013.36

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Copyright © 2013 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/

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Knockdown of RON delays but does not prevent tumor progression and metastasis. (a) Representative luciferase images of mice at 1, 3, 5 and 7 weeks after orthotopically implanted with Bx/vector-Luc or Bx/shRON-Luc cells. (b) Representative luciferase images of mice at week 9 after implanted with Bx/shRON-Luc cells. (c) Immunohistochemistry staining of RON-β and MET of the primary tumor sections from Bx/shRON cells at week 9 after implantation. RON remains low, but MET is highly expressed in these tumors.