Table 1.
Studya | Year | Country | n | Setting | Median(IQR) CD4 count (cells/μL) | Median follow-up (months) | On-treatment survival proportion |
Survival proportion at 12 months of ART |
Temporal distribution of deaths | Losses to follow-up | ||
---|---|---|---|---|---|---|---|---|---|---|---|---|
12m | 24m | CD4<50a | CD4>50a | |||||||||
Weidle [25] | 2002 | Uganda | 476 | Urban | 73 (15-187) | 3 | 0.74 | - | 0.67 | 0.82 | 57% deaths in first 3 m | 24% |
Djomand [30] | 2003 | Cote D'Ivoire | 480 | Urban | [37% <50] | 6 | 0.84 | - | - | - | - | Not reported |
Seyler [31] | 2003 | Cote D'Ivoire | 101 | Urban | 135 (55-221) | 17 | - | - | 0.80 | 0.96 | 50% deaths in first 3.3 m | Not reported |
Coetzee[10] | 2004 | S. Africa | 287 | Urban | 43 (13-94) | 13.9 | 0.86 | 0.86 | 0.82 | 0.91 | 71% deaths in first 3 m | 2% |
Laurent [40] | 2005 | Senegal | 176 | Urban | 144 (58-224) | 30 | - | 0.84 | - | - | Median time to death 9 m | Not reported |
Wester [11] | 2005 | Botswana | 153 | Urban | 96 (33-165) | 12 | 0.85 | - | 0.76 | 0.90 | Majority of deaths in first 6 m | 8% at 12 mc |
Lawn[22] | 2006 | S. Africa | 927 | Urban | 100 (47-160) | 7 | 0.91 | 0.90 | 0.85 | 0.94 | 87% between enrolment and first 4 m ART | 2% |
Ferradini [24] | 2006 | Malawi | 1308 | Rural | 112 (59-176) | 8.3 | 0.81 | 0.72 | - | - | 77% deaths in first 6 m | 5% at 12 mc |
Etard [23] | 2006 | Senegal | 404 | Urban | 128 (54-127) | 46 | 0.88 | 0.83 | 0.80 | 0.90 | 50% deaths in first 12 m | 2% at 12 m |
Stringer [6] | 2006 | Zambia | 16,198 | Urban | 147 (69-268) | 7 | 0.82 | - | 0.80 | - | 71% within first 3 m | Not reported |
Zachariah [35] | 2006 | Malawi | 1507 | Rural | 123 (58-206) | 10b | 0.87 | - | 0.77 | 0.92 | 61% in first 3 m; 79% in first 6m | 3% |
Makombe [95] | 2007 | Malawi | 4580 | Rural | - | 12 | 0.87 | - | - | - | >90% in first 6 m | 11% at 12 m |
Bajunirwe [37] | 2007 | Uganda | 398 | Rural | - | - | 0.76 | 0.71 | - | - | - | Not reported |
De Iaco [32] | 2007 | Burkina Faso | 315 | Urban | 97 | 18 | 0.69 | 0.83 | - | - | Mortality rate 2.3-fold higher in first 6 m ART | Not reported |
Johannessen [36] | 2007 | Tanzania | 336 | Rural | - | 12 | 0.74 | 0.68 | - | - | 60% deaths in first 3 m | 11% |
Kambugu [51] | 2007 | Uganda | 559 | Urban | 104 | 12 | 0.86 | - | - | - | 73% in first 6 m | Not reported |
Moore [39] | 2007 | Uganda | 1120 | Rural | 127 | 24 | 0.92 | 0.91 | - | - | 68% in first 6 m | Not reported |
Toure [8] | 2008 | Cote D'Ivoire | 10,211 | Urban | 123 (47-207) | 7.7 | - | - | 0.76 | >0.86 | 75% in first 4.6 m | 19% total losses at 12 mc |
CD4 cell counts in cells/μL.
Mean (SD).
Kaplan-Meier estimate.
m = months.