Table 2.

Blood pressure as a predictor of change in eGFR_cys in ml/min/1.73 m²/year (linear regression)

Continuous blood pressure measures	ΔeGFRcys
	Full cohort		Stratified by hypertensive medication use at baseline
			No (n = 2,371)		Yes (n = 1,994)
	β (95% CI)	P value	β (95% CI)	P value	β (95% CI)	P value
Systolic blood pressure (per 10mm Hg)†
Unadjusted	–0.15 (–0.20, –0.10)	<0.001	–0.17 (–0.25, –0.08)	<0.001	–0.15 (–0.20, –0.09)	<0.001
Demo adjusteda	–0.14 (–0.19, –0.09)	<0.001	–0.16 (–0.24, –0.07)	0.001	–0.13 (–0.19, –0.08)	<0.001
Fully adjustedb	–0.13 (–0.19, –0.08)	<0.001	–0.13 (–0.22, –0.04)	0.004	–0.13 (–0.19, –0.08)	<0.001
Diastolic blood pressure (per 10mm Hg)‡
Unadjusted	–0.09 (–0.19, 0.01)	0.080	–0.16 (–0.32, –0.004)	0.045	–0.01 (–0.12, 0.10)	0.865
Demo adjusteda	–0.10 (–0.20, 0.03)	0.056	–0.18 (–0.34, –0.017)	0.031	–0.01 (–0.12, 0.10)	0.801
Fully adjustedb	–0.10 (–0.20, 0.01)	0.051	–0.17 (–0.33, 0.001)	0.051	–0.03 (–0.14, 0.08)	0.631
Pulse pressure (per 10mm Hg)§
Unadjusted	–0.17 (–0.23, –0.11)	<0.001	–0.16 (–0.26, –0.06)	0.002	–0.19 (–0.25, –0.13)	<0.001
Demo adjusteda	–0.16 (–0.22, –0.10)	<0.001	–0.15 (–0.25, –0.04)	0.007	–0.18 (–0.25, –0.12)	<0.001
Fully adjustedb	–0.15 (–0.21, –0.09)	<0.001	–0.12 (–0.23, –0.01)	0.029	–0.18 (–0.24, –0.11)	<0.001

Abbreviation: CI, confidence interval.

^aAdjusted for age, gender, race.

^bAdjusted for age, gender, race, body mass index, smoking, diabetes mellitus, prevalent cardiovascular disease, low-density lipoprotein, and high-density lipoprotein .

†P value for interaction between systolic blood pressure and hypertensive medications = 0.802.

‡P value for interaction between diastolic blood pressure and hypertensive medications = 0.191.

§P value for interaction between pulse pressure and hypertensive medications = 0.419.