. Author manuscript; available in PMC: 2013 Nov 4.

Published in final edited form as: Future Med Chem. 2012 Sep;4(14):10.4155/fmc.12.108. doi: 10.4155/fmc.12.108

Table 1. Binding affinities and functional efficacies of oxytocin and arginine-vasopressin on the human receptor family.

Peptide	h-OTR		h-V_1aR		h-V_1bR		h-V₂R
	K_i [nM]^†	EC₅₀ [nM]	K_i	EC₅₀	K_i	EC₅₀	K_i	EC₅₀
Oxytocin	0.79–1.5	9.0–10.8	37–503	59.7	222–1782	24.5	823–3500	– ^‡

Vasopressin	1.7–110	8.3–15	0.6–1.1	0.24	0.09–0.68	2.0–4.3	1.2–4.9	0.05

^†

Binding data of all four receptors represent inhibitory constant (K_i) or dissociation constant (K_d).

^‡

Not available.

Data taken from [13,15,20-22].