. Author manuscript; available in PMC: 2013 Nov 4.

Published in final edited form as: Future Med Chem. 2012 Sep;4(14):10.4155/fmc.12.108. doi: 10.4155/fmc.12.108

Table 3. Sequence diversity and distribution of naturally occurring oxytocin-like nonapeptides.

graphic file with name emss-55385-t0001.jpg

Peptide	Sequence^‡	Organism(s)	Ref.^§
Oxytocin	CYIQNCPLG* CYIQNCPPG*	Eutherian mammals Monkeys	P01178 G0ZNF6
Valitocin	CYIQNCPVG*	Squalus acanthias	P43000
Aspartocin	CYINNCPLG*	Squalus acanthias	P42999
Asvatocin	CYINNCPVG*	Cartilaginous fish	P42996
Phasitocin	CYFNNCPIG*	Triakis scyllium	Q6F4F6
Phasvatocin	CYFNNCPVG*	Scyliorhinus caniculus	P42997
Cephalotocin	CYFRNCPIG*	Octopus vulgaris	P80027
Octopressin	CFWTSCPIG*	Octopus vulgaris	Q76DN1
Seritocin	CYIQSCPIG*	Amietophrynus regularis	P42995
Glumitocin	CYISNCPQG*	Cartilaginous fish	P42994
Mesotocin	CYIQNCPIG* CYFQNCPIG*	Lungfishes and marsupials Setonix brachyurus	P08162 0909223A^¶
Val4-mesotocin	CYIVNCPIG*	Plethodon shermani	A5A4K4
Phe-mesotocin	CFIQNCPIG*	Neoceratodus forsteri	O57388
Isotocin	CYISNCPIG*	Osteichthyes	P42993
Annetocin^#	CFVRNCPTG*	Eisenia foetida	P42998
Vasotocin (ancestral)^††	CYIQNCPRG*	Nonmammalian vertebrates	P69129

^†

Relative frequency sequence logo plot, conserved cysteine residues are highlighted in yellow, hydrophobic, aromatic and non-polar amino acids are labeled in gray and positively charged residues are labeled in red. All sequences are amidated at the C-terminus, as indicated by the asterisk.

^‡

Conserved cysteine residues forming a disulfide bond are highlighted in bold. All sequences are amidated at the C-terminus, as indicated by the asterisk.

^§

UniProtKB entry, unless otherwise stated.

^¶

GenBank protein accession number.

Denoted also as Annepressin [1].

^††

Presumed ancestral oxytocin/vasopressin nonapeptide [2].