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. Author manuscript; available in PMC: 2013 Nov 4.
Published in final edited form as: Am J Transplant. 2011 Aug 10;11(11):10.1111/j.1600-6143.2011.03683.x. doi: 10.1111/j.1600-6143.2011.03683.x

Figure 2. Achievement of chimerism and tolerance with an extensive costimulatory blockade regimen in presensitized μMT B6 mice.

Figure 2

(A) Mean percent repopulation of donor cells in each WBC lineage in presensitized μMT B6 mice over time as measured by flow cytometry. μMT B6 mice presensitized with B10.A skin received anti-CD8, anti-CD4, anti-NK1.1, anti-CD40L and anti-OX40L mAbs along with 3 Gy TBI and 80 × 106 B10.A BMCs. Twelve of 15 mice receiving the extensive costimulatory blockade regimen achieved chimerism. Nonchimeras are excluded from mean values. (B) Donor and third-party skin graft (SG) survival in B10.A→μMT B6 chimeras. Four of five chimeric mice accepted donor-type SGs for 100 days. Also shown are donor and third-party SG survival of B10.A→wild-type B6 failed chimeras prepared with the same regimen. Skin was grafted 8 weeks after BMT.