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. Author manuscript; available in PMC: 2013 Nov 4.
Published in final edited form as: Pure Appl Chem. 2011 Jul 10;83(9):10.1351/PAC-CON-10-12-07. doi: 10.1351/PAC-CON-10-12-07

Fig. 4.

Fig. 4

Schematic summary of electrical charge–oriented receptor selectivity of L1 and L5. L1 is endocytosed by the normal LDLR through interaction between the basic residues of apoB100 on L1 (normal LDL) and the negatively charged residues of LDLR, resulting in LDL degradation and utilization of cholesterol and phospholipids for biological purposes. In contrast, L5 (modified LDL) is internalized by means of the interaction between the negatively charged surface of L5 and the positively charged lectin-like domain of LOX-1, resulting in cell apoptosis.