Table 1. Increased miRNA Expression in Alcoholics Relative to Non-Alcoholic Controls.

miRNA	Fold Change	p-value	Genomic Coordinates
hsa-miR-375	2.8	0.0007	2:219866367-219866430 (-)
hsa-miR-3065-5p	2.7	0.001	17:79099677-79099755 (+)
hsa-miR-488-star	2.0	0.003	1:176998499-176998581 (-)
hsa-miR-299-3p	2.0	0.003	14:101490131-101490193 (+)
hsa-miR-377	1.9	0.001	14:101528387-101528455 (+)
has-mir-516a-2*	1.7	0.002	19:54264387-54264476 (+)
hsa-miR-767-5p	1.7	0.002	X:151561893-151562001 (-)
hsa-miR-493	1.7	0.00005	14:101335397-101335485 (+)
hsa-miR-379	1.5	0.003	14:101488403-101488469 (+)
hsa-miR-105*	1.5	0.0009	Chromosome 7
hsa-miR-29b*	1.5	0.001	2 loci on chromosomes 7
hsa-miR-149	1.5	0.002	2:240227157-240227240 (+)

Expression ≥1.5 fold increased among alcoholics relative to control brain. miRNAs linked to the maternally imprinted region 14q32 shown in italics.

^*represents those miRNAs whose precursors occur in a cluster of 2 (mir-105, mir-29b, mir-516a) transcripts at the same genetic coordinates. (+)=sense direction, (-)=anti-sense direction. Microarray data processed using RMA followed by multiple linear regression. FDR cutoff ≤ 0.3.