Table 2. Expression of Target Genes by Up-regulated miRNAs in Alcoholism.
| miRNA | Fold Change | mRNA Expression Target | Fold Change | Chromosome Band |
|---|---|---|---|---|
| miR-375(2q35) | 2.8 | transferrin (TF) | -3.9 | 3q22.1 |
| blood vessel epicardial substance (BVES) | -2.5 | 6q21 | ||
| chloride channel accessory 4 (CLCA4) | -2.1 | 1p31-p22 | ||
| transmembrane and tetratricopeptide repeat containing 2 (TMTC2) | -1.9 | 12q21.31 | ||
| phosphodiesterase 8A (PDE8A) | -1.9 | 15q25.3 | ||
| SLAIN motif family, member 1 (SLAIN1) | -1.8 | 13q22.3 | ||
| EGF-like repeats and discoidin I-like domains 3 (EDIL3) | -1.8 | 5q14 | ||
| chimerin (chimaerin) 2 (CHN2) | -1.6 | 7p15.3 | ||
| inositol hexakisphosphate kinase 3 (IP6K3) | -1.5 | 6p21.31 | ||
| calcineurin-like phosphoesterase domain containing1 (CPPED1) | -1.5 | 16p13.12 | ||
| miR-3065(17q25.3) | 2.7 | UDP glycosyltransferase 8 (UGT8) | -3.7 | 4q26 |
| catenin (cadherin-associated protein), alpha 3 (CTNNA3) | -3.3 | 10q22.2 | ||
| thrombospondin 2 (THBS2) | -2.1 | 6q27 | ||
| transmembrane protein 206 (TMEM206) | -1.7 | 1q32.3 | ||
| BCL2-related ovarian killer (BOK) | -1.7 | 2q37.3 | ||
| miR-488-star(1q25.2) | 2.0 | ribonuclease, RNase A family, 1 (RNASE1) | -2.6 | 14q11.2 |
| dedicator of cytokinesis 5 (DOCK5) | -2.5 | 8p21.2 | ||
| lysophosphatidic acid receptor 1 (LPAR5) | -2.3 | 9q31.3 | ||
| Ras association (RalGDS/AF-6) domain family member 2 (RASSF2) | -2.3 | 20p13 | ||
| solute carrier family 44, member 1 (SLC44A1) | -2.2 | 9q31.2 | ||
| chromosome 13 open reading frame 31 (C13ORF31) | -2.1 | 13q14.11 | ||
| inducible T-cell co-stimulator ligand (ICOSLG) | -2.0 | 21q22.3 | ||
| sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (SEMA4D) | -2.0 | 9q22.2 | ||
| phosphodiesterase 8A (PDE8A) | -1.9 | 15q25.3 | ||
| EF-hand domain family, member D1 (EFHD1) | -1.9 | 2q37.1 | ||
| transmembrane and tetratricopeptide repeat containing 2 (TMTC2) | -1.9 | 12q21.31 | ||
| transmembrane and coiled-coil domain family 3 (TMCC3) | -1.8 | 12q22 | ||
| EGF-like repeats and discoidin I-like domains 3 (EDIL3) | -1.8 | 5q14 | ||
| proline rich 5 like (PRR5L) | -1.7 | 11p13-p12 | ||
| chimerin (chimaerin) 2 (CHN2) | -1.6 | 7p15.3 | ||
| SHC (Src homology 2 domain containing) family, member 4 (SHC4) | -1.6 | 15q21.1-21.2 | ||
| presenilin 1 (PSEN1) | -1.6 | 14q24.3 | ||
| miR-299-3p(14q32) | 2.0 | chromosome 21 open reading frame 91 (C21orf91) | -3.1 | 21q21.1 |
| ectonucleotide pyrophosphatase 2 (ENPP2) | -3.4 | 8q24.1 | ||
| carnosine dipeptidase 1 (metallopeptidase M20 family) (CNDP1) | -2.6 | 18q22.3 | ||
| lysophosphatidic acid receptor 1 (LPAR1) | -2.4 | 9q31.3 | ||
| engulfment and cell motility 1 (ELMO1) | -1.8 | 7p14.1 | ||
| dihydropyrimidinase-like 5 (DPYSL5) | -1.7 | 2p23.3 | ||
| DIX domain containing 1 (DIXDC1) | -1.5 | 11q23.1 | ||
| miR-377(14q32) | 1.9 | UDP glycosyltransferase 8 (UGT8) | -3.7 | 4q26 |
| chromosome 21 open reading frame 91 (C21orf91) | -3.1 | 21q21.1 | ||
| anillin, actin binding protein (ANLN) | -3.5 | 7p15-p14 | ||
| ring finger protein 125 (RNF125) | -2.4 | 18q12.1 | ||
| chloride channel accessory 4 (CLCA4) | -2.1 | 1p31-p22 | ||
| nudE nuclear distribution gene (NDE1) | -2.1 | 16p13.11 | ||
| chromosome 13 open reading frame 31 (C13orf31) | -2.1 | 13q14.11 | ||
| sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (SEMA4D) | -2.0 | 9q22.2 | ||
| transmembrane and tetratricopeptide repeat containing 2 (TMTC2) | -1.9 | 12q21.31 | ||
| transmembrane and coiled-coil domain family 3 (TMCC3) | -1.8 | 12q22 | ||
| EGF-like repeats and discoidin I-like domains 3(EDIL3) | -1.8 | 5q14 | ||
| engulfment and cell motility 1 (ELMO1) | -1.8 | 7p14.1 | ||
| chimerin (chimaerin) 2 (CHN2) | -1.6 | 7p15.3 | ||
| MID1 interacting protein 1 (gastrulation specific G12 homolog (zebrafish), MID1IP1) | -1.6 | Xp11.4 | ||
| miR-767-5p(Xq28) | 1.7 | ectonucleotide pyrophosphatase/phosphodiesterase2 (ENPP2) | -3.4 | 8q24.1 |
| miR-379(14q32) | 1.5 | sema domain, immunoglobulin domain (Ig), | -2.0 | 9q22.2 |
| transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (SEMA4D) | ||||
| 2′,3′-cyclic nucleotide 3′ phosphodiesterase (CNP) | -2.0 | 17q21 | ||
| transmembrane and coiled-coil domain family 3 (TMCC3) | -1.8 | 12q22 | ||
| miR-105(Xq28, 2 genes) | 1.5 | phosphatidic acid phosphatase type 2C (PPAP2C) | -1.7 | 19p13 |
| miR-29b(7q32.3 or1q32.2) | 1.5 | ectonucleotide phosphodiesterase 2 (ENPP2) | -3.4 | 8q24.1 |
| carnosine synthase 1 (CARNS1) | -2.9 | 11q13.2 | ||
| myelin oligodendrocyte glycoprotein (MOG) | -2.9 | 6p22.1 | ||
| thrombospondin 2 (THBS2) | -2.1 | 6q27 | ||
| CKLF-like MARVEL transmembrane domain containing 5 (CMTM5) | -2.1 | 14q11.2 | ||
| sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic | -2.1 | 14q11.2 | ||
| domain, (semaphorin) 4D (SEMA4D) | -2.0 | 9q22.2 | ||
| dishevelled associated activator of morphogenesis 2 (DAAM2) | -2.0 | 6p21.2 | ||
| proteolipid protein 1 (PLP1) | -1.8 | Xq22 | ||
| dihydropyrimidinase-like 5 (DPYSL5) | -1.7 | 2p23.3 | ||
| DIP2 disco-interacting protein 2 homolog B (DIP2B) | -1.6 | 12q13.12 | ||
| presenilin 1 (PSEN1) | -1.6 | 14q24.3 | ||
| MAP6 domain containing 1 (MAP6D1) | -1.6 | 3q27.1 | ||
| DIX domain containing 1 (DIXDC1) | -1.5 | 11q23.1 | ||
| miR-149 (2q37.2) | 1.5 | potassium voltage-gated channel, subfamily H (eag-related), member 8 (KCNH8) | -2.8 | 3p24.3 |
| CD22 molecule (CD22) | -2.7 | 19q13.1 | ||
| solute carrier organic anion transporter family, member 1A2 (SLCO1A2) | -2.7 | 12p12 | ||
| v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian) (ERBB3) | -2.7 | 12q13 | ||
| chromosome 11 open reading frame 9 (C11orf9) | -2.5 | 11q12-q13.1 | ||
| dedicator of cytokinesis 10 (DOCK10) | -2.1 | 2q36.2 | ||
| CKLF-like MARVEL transmembrane domain containing 5 (CMTM5) | -2.1 | 14q11.2 | ||
| PX domain containing serine/threonine kinase (PXK) | -2.0 | 3p14.3 | ||
| EF-hand domain family, member D1 (EFHD1) | -1.9 | 2q37.1 | ||
| kinesin family member 13B (KIF13B) | -1.9 | 8p12 | ||
| UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) (GALNT6) | -1.7 | 12q13 | ||
| BCL2-related ovarian killer (BOK) | -1.7 | 2q37.3 | ||
| arrestin domain containing 2 (ARRDC2) | -1.6 | 19p13.11 | ||
| ring finger protein 220 (RNF220) | -1.5 | 1p34.1 | ||
| miR-3162-3p (11q12.1) | -2.8 | BCL2-related ovarian killer (BOK) | -1.7 | 2q37.3 |
| miR-1227 (19p13.3) | -1.5 | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D (SEMA4D) | -2.0 | 9q22.2 |
| phosphodiesterase 6B, cGMP-specific, rod, beta (PDE6B) | -1.6 | 4p16.3 |
miRNA data were processed using RMA followed by multiple linear regression. Exon-arrays were RMA-background corrected, quantile-normalized and gene-level summarized using the Median Polish algorithm followed by linear regression. Target expression source information from: microRNA.org in normal text; targetscan.org shown in italics; or identified in both search engines shown in bold.