Fig. 4.

mOFC–PAG coupling strength was associated with opposite modulation of SII in placebo analgesia and hyperhedonia. Strong placebo-induced functional coupling between mOFC and PAG (A) correlated with increased SII responses to stroking touch (B) but decreased SII responses to painful touch (C), a pattern that was replicated also for the pINS. Averaged activation maps were thresholded at Z > 2, uncorrected, for illustrational purposes. The scatterplots illustrate the correlations, which are significantly different from each other. *P > 0.05.