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. 2013 Oct 16;110(44):E4134–E4141. doi: 10.1073/pnas.1317042110

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Fig. 4. — Reduction of CENP-E in Mad2^+/− cells and mice leads to high CIN and tumor suppression. (A) Quantitation of aberrant mitotic figures in primary MEFs of the indicated genotypes (mean ± SEM. n = 4). (B) (Left) Frequency of splenic lymphomas in CENP-E^+/−;Mad2^+/− doubly heterozygous or CENP-E^+/− or Mad2^+/− singly heterozygous mice. H&E-stained tissue sections of normal spleen (Center) and splenic lymphoma (Right) (*P < 0.05). (C) (Left) Frequency of lung adenomas is diminished in CENP-E^+/−;Mad2^+/− mice with the highest level of CIN; H&E-stained tissue sections of normal lung (Center) and lung adenoma (Right) (n = 30 wild-type, 30 CENP-E^+/−, 19 Mad^+/−, and 21 CENP-E^+/−;Mad2^+/−). *P < 0.05 in all panels.